Publications by authors named "A N Trefilova"
Event rates and incidence of post-COVID-19 condition in hospitalised SARS-CoV-2 positive children and young people and controls across different pandemic waves: exposure-stratified prospective cohort study in Moscow (StopCOVID).
BMC Med
February 2024
Article Synopsis
- - The study aimed to explore long-term health outcomes in children and young people post-COVID-19, particularly focusing on post-COVID-19 condition (PCC) and incomplete recovery, comparing these outcomes with those from other non-SARS-CoV-2 infections.
- - Conducted in Moscow, researchers followed two cohorts of pediatric patients with confirmed COVID-19 from two different time periods (Wuhan and Omicron variants) and compared them to a reference group of those with other infections but negative for SARS-CoV-2.
- - Findings revealed that the incidence of PCC was significantly higher in the Wuhan variant group compared to the reference group, while the Omicron variant showed no significant difference in PCC outcomes when compared to the
Background: Formally belonging to the non-steroidal anti-inflammatory drug class pyrazolones have long been used in medical practices.
Objective: Our goal is to synthesize N-methylated 1-aryl-3-polyfluoroalkylpyrazolones as fluorinated analogs of antipyrine, their isomeric O-methylated derivatives resembling celecoxib structure and evaluate biological activities of obtained compounds.
Methods: In vitro (permeability) and in vivo (anti-inflammatory and analgesic activities, acute toxicity, hyperalgesia, antipyretic activity, "open field" test) experiments.
We have developed the convenient methods for synthesis of polyfluorosalicylic acids and their derivatives. For the first time the biological properties of polyfluorosalicylates were investigated in vitro (permeability through the biological membranes, COX-1 inhibitory action) and in vivo (anti-inflammatory, analgesic activities, acute toxicity). Molecular docking of polyfluorinated salicylates confirmed in vitro and in vivo experiments.
View Article and Find Full Text PDFCircadian rhythms of saliva melatonin in ADHD, anxious and normal children.
Neuro Endocrinol Lett
April 2012
Background: Attention-deficit/hyperactivity disorder (ADHD) and anxiety disorders are the most frequent psychiatric disorders in children. Changes in rhythms of symptoms during the day may be influenced by genetic, biological and psychological factors. Some changes of melatonin rhythm may hypothetically change the activity of ADHD by changing arousal or in anxiety children by changing their emotional state.
View Article and Find Full Text PDF[Continuous system of postgraduate education of physicians in Udmurt Republic].
Probl Sotsialnoi Gig Istor Med
August 1997
Presents the experience gained by the Izhevsk Medical Institute in two-year training of general practitioners (family physicians): versatile training programs have been developed, as well as individual legislative problems. The program is supplied with training and therapeutic base.
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