Delamination Detection and Localization in Vibrating Composite Plates and Shells Using the Inverse Finite Element Method.

Delamination damage is one of the most critical damage modes of composite materials. It takes place through the thickness of the laminated composites and does not show subtle surface effects. In the present study, a delamination detection approach based on equivalent von Mises strains is demonstrated for vibrating laminated (i.

NAD metabolism drives astrocyte proinflammatory reprogramming in central nervous system autoimmunity.

Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS). Astrocytes are the most abundant glial cells in the CNS, and their dysfunction contributes to the pathogenesis of MS and its animal model, experimental autoimmune encephalomyelitis (EAE). Recent advances highlight the pivotal role of cellular metabolism in programming immune responses.

Astrocyte immunometabolic regulation of the tumour microenvironment drives glioblastoma pathogenicity.

Malignant brain tumours are the cause of a disproportionate level of morbidity and mortality among cancer patients, an unfortunate statistic that has remained constant for decades. Despite considerable advances in the molecular characterization of these tumours, targeting the cancer cells has yet to produce significant advances in treatment. An alternative strategy is to target cells in the glioblastoma microenvironment, such as tumour-associated astrocytes.

Shape Sensing of Plate Structures Using the Inverse Finite Element Method: Investigation of Efficient Strain-Sensor Patterns.

Methods for real-time reconstruction of structural displacements using measured strain data is an area of active research due to its potential application for Structural Health Monitoring (SHM) and morphing structure control. The inverse Finite Element Method (iFEM) has been shown to be well suited for the full-field reconstruction of displacements, strains, and stresses of structures instrumented with discrete or continuous strain sensors. In practical applications, where the available number of sensors may be limited, the number and sensor positions constitute the key parameters.

Application of Inverse Finite Element Method to Shape Sensing of Curved Beams.

Curved beam, plate, and shell finite elements are commonly used in the finite element modeling of a wide range of civil and mechanical engineering structures. In civil engineering, curved elements are used to model tunnels, arch bridges, pipelines, and domes. Such structures provide a more efficient load transfer than their straight/flat counterparts due to the additional strength provided by their curved geometry.