[Sudden Cardiac Death in Patients With Hypertrophic Cardiomyopathy].

This literature review is devoted to the problem of studying sudden cardiac death (SCD) in hypertrophic cardiomyopathy (HCM). It covers prevalence of SCD and its structure among young individuals and trained athletes, contains discussion of relation of SCD to sex, age, and hypertrophic response of myocardium to physical exercise. Modern views on arrhythmogenic substrate underlying SCD in HCM as well as pathophysiologic cascade of life-threatening ventricular tachyarrhythmia are presented in detail.

[The role of T-wave alternans in prognosis of risk of sudden cardiac death].

The literature review contains data dedicated to one of tools of stratification of risk of fatal arrhythmia - detection of T-wave alternans (TWA). Methods of determination of TWA, problems of results interpretation, mechanism of the TWA genesis, and its clinical meaning in different cardiovascular diseases are considered. Special attention is paid to the role of TWA in the identification of the patients who require cardioverter-defibrillator implantation.