[Attraktive and aversive for intact individuals volatile excretion of male mice induced a thymus dependent antigen].

Immunization of male mice of the CBA and C57BL/6J strains with sheep red blood cells (SRBC) induce excretion of urinary volatile components (VC), modifying the behavioral reactions of intact males CBA strain. In early times after injection of 1 x 10(8) SRBC per mouse results in secretion of attractive VC, whereas injection of 1 x 10(9) cells per mice induces secretion of aversive VC. Regular for normal and the observed also in the early stages of attraction of intact males CBA to VC immunized syngeneic males CBA (relatively VC immunized with allogeneic C57BL/6) was lost from 3 to 14th day after the introduction of SRBC in the dose of 1 x 10(8) cells/mice and with the 9th on the 14th day after the introduction of SRBC in the dose of 1 x 10(9).

[Effect of radiation-induced bystander chemosignals of mice on the humoral immune response in spleen and lymph nodes of intact recipients].

The ability of post-radiation (4 Gy) bystander chemosignals (the volatile components of mouse urine) to distantly modulate the humoral immune response to the sheep red blood cells in the spleen and popliteal lymph nodes of intact recipients has been investigated. It was shown that the exposure of animals to chemosignals before antigen injection resulted in the decrease and increase of the immune response in the spleen and lymph nodes, respectively. When animals were exposed to chemosignals after the antigenic stimulus, an increased immune response was observed in both spleen and lymph nodes.

[Effect of volatile excretions induced with thymus-dependent antigen in female mice on the behavioural responses of males].

It was found that thymus-dependent antigen sheep red blood cells in the optimal immunogenic dose (1 x 10(8) cells/mouse) induced in female mice of CBA and B6 strain secretion of attractive urinary volatile components (VCs), and in the supraoptimal dose (1 x 10(9) cells/mouse)--aversive VCs for intact males CBA strain. In a direct comparison of the properties ofVCs-immunized mice of CBA and B6, a modification of the effect of constitutive chemosignalling: disturbance of ability of females VCs to attract allogeneic males, was observed. The role of thymus-dependent antigen dose and sex of animals in the mechanism of generation of antigen-induced chemosignals is discussed.

[The influence of postradiation chemical signals of mice on the humoral immune response in recipients in different time relative to antigenic stimulus].

The influence of volatile urine chemosignals of irradiated (4 Gy) mice on the primary humoral immune response to sheep red blood cells in intact recipients was investigated. It was demonstrated that the direction of immunomodulatory effect is dependent upon the time at which the postradiation chemosignals was initially applied. The antibody response to antigen was markedly suppressed in mice that were exposed before antigen injection.

[Experimental study of the radioprotective action of melanin on the somatic development during irradiation in the antenatal period of ontogenesis].

Daily introduction per os of the exogenous melanin in a doze of weight of 10 mg/kg pregnant female rats Wistar eliminated the functional deficiency of somatic development revealed at posterity at chronic gamma-irradiation in a doze 1.00-1.25 Gy for all period of pregnancy.