[A look at the problem of surgical treatment of renal cel carcinoma in the aspect of biomolecular diagnosis and assessment of renal function].

The article reviews the domestic and international literature on the issues of biomolecular diagnosis of acute renal injury in the perioperative period in patients with renal cell carcinoma (RCC). Emerging opportunities for early detection of tumors make even more relevant the use of minimally invasive interventions. Of equal importance is the assessment of renal function in patients with diagnosed RCC and the prediction of acute renal injury and progression of chronic kidney disease in the postoperative period.

[Monocytic chemotaxic protein-1 and beta2-microglobulin: a role in estimation of renal parenchyma damage in surgical treatment of nephrolithiasis].

To estimate renal damage and intensity of tubulointerstitial fibrosis basing on the data of modern molecular markers in surgical treatment of nephrolithiasis, we examined the results of surgical treatment of 200 nephrolithiasis patients divided into 5 groups by the method of surgery. We estimated content of molecular mediators of nephrofibrosis in the urine and severity of renal dysfunction. We were the first to follow up urinary excretion of proinflammatory and profibrotic monocytic chemoattractant protein-1 (MCP-1) and low-molecular protein beta-2-microglobulin which is a reliable indicator of tubular impairment.

[Endothelial dysfunction in urolithiasis patients].

To characterize endothelial dysfunction in operated nephrolithiasis patients, we studied NO, VEGF, ET-1, IL-6 concentration in the blood serum and NO in the urine of nephrolithiasis patients divided into three groups by the type of surgical treatment before operation, 7-10 days and 1 month after it. We used beta-2 microglobulin as an indicator of tubular dysfunction. We found a significant rise of a concentration of the endothelial dysfunction markers ET-1, IL-6 and VEGF in the blood serum (p < 0.