Publications by authors named "A N Radhakrishnan"
Background: The role of imaging in autoimmune encephalitis (AIE) remains unclear, and there are limited data on the utility of magnetic resonance imaging (MRI) to diagnose, treat, or prognosticate AIE.
Purpose: To evaluate whether MRI is a diagnostic and prognostic marker for AIE and assess its efficacy in distinguishing between various AIE subtypes.
Material And Methods: We analyzed data from 96 AIE patients from our prospective autoimmune registry.
Article Synopsis
- Radiation therapy (RT) is crucial for cancer treatment but often damages surrounding normal tissues, leading to complications like fibrosis and decreased organ function.
- Conventional RT promotes epithelial-mesenchymal transition (EMT), which is linked to tissue damage and cancer progression.
- FLASH radiation therapy (FLASH-RT) offers a promising alternative by delivering high doses rapidly, potentially reducing normal tissue damage while preserving regenerative capacity and mitigating fibrosis through improved regulation of EMT pathways.
Cancer continues to pose a formidable challenge in global health due to its incidence and increasing resistance to conventional therapies. A key factor driving this resistance is tumor hypoxia, characterized by reduced oxygen levels within cancer cells. This hypoxic environment triggers a variety of adaptive mechanisms, significantly compromising the efficacy of cancer treatments.
View Article and Find Full Text PDFCholesterol is a critical lipid that is present at high concentrations in the plasma membranes of animal cells. Most of the membrane cholesterol is sequestered by other membrane lipids and the transmembrane domains of proteins. Cholesterol in excess of such sequestration forms a pool that is referred to as "accessible cholesterol.
View Article and Find Full Text PDFPurpose: Very little is known about primary care involvement in the care of cancer survivors beyond the initial 5 years post-treatment when transitioning to primary care is guideline-recommended for many survivors.
Methods: The ICanCare study is a longitudinal survey of women diagnosed with breast cancer in 2014-2015 identified in the Georgia and Los Angeles SEER registries. Women were surveyed during initial treatment and again approximately 6 years later in survivorship (2021-2022; n = 1,412, 60% response rate).