Relation of MRI visible perivascular spaces with global and regional brain structural connectivity measures: The Framingham Heart Study (FHS).

MRI visible perivascular spaces (PVS) are associated with cognitive impairment and dementia, which are also associated with disrupted network connectivity. PVS may relate to dementia risk through disruption in brain connectivity. We studied the relation between PVS grade and global and regional structural connectivity in Framingham Heart Study participants free of stroke and dementia.

Meliponini Geopropolis Extracts Induce ROS Production and Death in Promastigotes and Axenic Amastigotes In Vitro.

Leishmania amazonensis, a cause of cutaneous leishmaniasis in Brazil, is a neglected disease with toxic and inconsistently effective treatments. The parasite's survival depends on managing oxidative stress, making redox-regulating enzymes potential therapeutic targets. Geopropolis, a resinous product from native stingless bees, shows promising antiparasitic effects.

Inactivation of Staphylococcus aureus by antimicrobial photodynamic therapy using 1,9-Dimethyl-Methylene Blue: in vitro and in vivo studies.

The efficiency of antibiotics in terms of their bacterial inhibition is well known. However, studies show that its overuse, underuse, and misuse induce antimicrobial resistance, promoting the need to work with alternative methods. In this sense, antimicrobial photodynamic therapy (aPDT) is a promising selective method demonstrating excellent response.

Dual versus single antiplatelet therapy in patients with nonminor ischemic stroke: a meta-analysis.

Background:  Patients with ischemic stroke present a higher risk of stroke recurrence, neurological deterioration, and death. The benefit of dual antiplatelet therapy (DAPT) over single antiplatelet therapy (SAPT) among patients with minor ischemic stroke is well established; however, robust evidence is lacking for those with nonminor stroke.

Objective:  To describe the benefits and risks of DAPT versus SAPT in patients with nonminor ischemic stroke.

Development of 3D-printed foods incorporating riboflavin-loaded whey protein isolate nanostructures: characterization and digestion.

3D printing has emerged as a groundbreaking technology, aiming to enhance sensory attributes and improving nutritional/functional aspects. Simultaneously, nano-delivery systems have emerged as an opportunity to protect bioactive compounds against degradation and improve their bioaccessibility. Therefore, a novel concept is underway, involving the 3D printing of perishable healthy foods previously fortified with bioactive compound-loaded nanostructures.