Publications by authors named "A N Pavlyuchenkova"
Article Synopsis
- Mast cells play a crucial role in allergic and inflammatory diseases, primarily through their activation by the interaction of antigens/allergens with IgE and the FcεRI receptor.
- This activation leads to the release of preformed mediators and the production of various new mediators, which are involved in the allergic response.
- There is growing interest in targeting mast cell activity through novel approaches, including manipulating autophagy and focusing on mitochondria, to improve treatments for allergic diseases.
Article Synopsis
- Inflammatory bowel disease (IBD) affects about 5% of the population in industrialized countries, with a focus on the role of the intestinal epithelial barrier's function in its development.
- The health of the intestinal epithelium relies on the self-renewal ability and the integrity of intercellular junctions, which are influenced by mitochondrial functions.
- Mitochondrial dysfunction may contribute to the structural issues in tight junctions and the cytoskeleton of intestinal cells, leading to impaired barrier function and the onset of IBD, but more research is needed to understand these processes.
There is accumulating evidence that mitochondria and mitochondrial STAT3 are involved in the activation of mast cells. The mitochondria-targeted curcuminoids Mitocur-1 and Mitocur-3 have been suggested to reduce antigen-dependent mast cell activation by inhibiting mitochondrial STAT3. The aim of the current work was to investigate the mechanisms of action of these mitocurcuminoids on mast cells and mitochondrial functions.
View Article and Find Full Text PDFAims: FcεRI-dependent activation and degranulation of mast cells (MC) play an important role in allergic diseases. We have previously demonstrated that triphenylphosphonium (TPP)-based antioxidant SkQ1 inhibits mast cell degranulation, but the exact mechanism of this inhibition is still unknown. This study focused on investigating the influence of TPP-based compounds SkQ1 and CTPP on FcεRI-dependent mitochondrial dysfunction and signaling during MC degranulation.
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