Radiotherapy (RT) has been shown to be a cornerstone of both palliative and curative tumor care. RT has generally been reported to be sharply limited by ionizing radiation (IR)-induced toxicity, thereby constraining the control effect of RT on tumor growth. FLASH-RT is the delivery of ultra-high dose rate (UHDR) several orders of magnitude higher than what is presently used in conventional RT (CONV-RT).
View Article and Find Full Text PDFActa Crystallogr B Struct Sci Cryst Eng Mater
December 2024
The crystal structures of nine hexamethyl-[1,1'-biphenyl]-4,4'-diammonium (HMB) salts are described: the iodide (2), triiodide (3), succinate (4), fumarate (5), tetravanadate (6), hydroterephthalate (7) and perylenetetracarboxylate (8), as well as pentamethyl-[1,1'-biphenyl]-4,4'-diammonium iodide (1) and the metal-organic framework sodium diacetylenedisalicylate-HMB (9). HMB carbonate (10) has been synthesized as an important intermediate for a promising anti-metal-organic framework (`anti-MOF'). All the described compounds are characterized by high solubility in water.
View Article and Find Full Text PDFA comparative study of oxidative stress markers (ischemia-modified albumin (IMA) and the blood serum antioxidant capacity) in normal pregnancy and preeclampsia was carried out. The IMA level and blood serum antioxidant capacity increased in the following order: healthy non-pregnant women→healthy pregnant women→patients with moderate preeclampsia→patients with severe preeclampsia (p<0.001).
View Article and Find Full Text PDFCirculating tumor DNA (ctDNA) represents a powerful measure of minimal residual disease (MRD) in colorectal cancer (CRC). Although immunotherapy has been widely established in metastatic CRC that is mismatch repair deficient or microsatellite instability-high (dMMR/MSI-H), its role in non-metastatic CRC is rapidly evolving. In resected, dMMR/MSI-H stage II CRC, adjuvant fluoropyrimidine has no benefit and is not recommended.
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