Publications by authors named "A N Nesterov"
Article Synopsis
- The U-21 strain secretes chaperones, like the ClpL protein, which shows potential as a disaggregase for treating Parkinson's disease.
- Analysis of the C0965_000195 gene reveals that ClpL can assist in refolding misfolded proteins, particularly luciferases, helping cells manage protein damage.
- Experiments indicate that both the secreted culture medium from U-21 and purified ClpL can protect proteins from denaturation, suggesting ClpL's key role in the strain’s potential therapeutic benefits.
In recent years, there has been an increasing tendency to create drugs based on certain commensal bacteria of the human microbiota and their ingredients, primarily focusing on live biotherapeutics (LBPs) and postbiotics. The creation of such drugs, termed pharmacobiotics, necessitates an understanding of their mechanisms of action and the identification of pharmacologically active ingredients that determine their target properties. Typically, these are complexes of biologically active substances synthesized by specific strains, promoted as LBPs or postbiotics (including vesicles): proteins, enzymes, low molecular weight metabolites, small RNAs, etc.
View Article and Find Full Text PDFTachycardia-induced cardiomyopathy (TIC) is a reversible subtype of dilated cardiomyopathy (DCM) resulting from sustained supraventricular or ventricular tachycardia and diagnosed by the normalization of left ventricular ejection fraction (LVEF) after stable sinus rhythm restoration. The aim of this study was to determine the contribution of cardiac magnetic resonance (CMR) to the differential diagnosis of TIC and DCM with persistent atrial arrythmias in patients hospitalized for the first time with heart failure (HF) with reduced LVEF of nonischemic origin. A total of 29 patients (age: 58.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates whether competition influences moral behavior, a topic that has produced mixed results in previous research due to varying experimental designs.
- Researchers collected data from over 18,000 participants across 45 different experimental setups, finding that competition has a small negative impact on moral behavior.
- The results highlight significant differences in effect sizes across studies, suggesting that relying on just one experimental design may not provide a clear understanding of the relationship between competition and morality.
Background: Pyridazine pyrazolecarboxamides (PPCs) are a novel insecticide class discovered and optimized at BASF. Dimpropyridaz is the first PPC to be submitted for registration and controls many aphid species as well as whiteflies and other piercing-sucking insects.
Results: Dimpropyridaz and other tertiary amide PPCs are proinsecticides that are converted in vivo into secondary amide active forms by N-dealkylation.