Publications by authors named "A N Larabi"
The fungal Bromodomain and Extra-Terminal (BET) protein Bdf1 is a potential antifungal target against invasive fungal infections. However, the need to selectively inhibit both Bdf1 bromodomains (BDs) over human orthologs and the lack of molecular tools to assess on-target antifungal efficacy hamper efforts to develop Bdf1 BD inhibitors as antifungal therapeutics. This study reports a phenyltriazine compound that inhibits both Bdf1 BDs from the human fungal pathogen Candida glabrata with selectivity over the orthologous BDs from the human BET protein Brd4.
View Article and Find Full Text PDFArticle Synopsis
- * Typhimurium invasion reduces the density of beneficial gut bacteria and leads to malabsorption of dietary amino acids, which affects nutrient availability in the large intestine.
- * Specific amino acids like lysine and ornithine can help Typhimurium survive by restoring pH balance, allowing it to invade even when beneficial microbiota are present.
The gut microbiota prevents harmful microbes from entering the body, a function known as colonization resistance. The enteric pathogen Salmonella enterica serovar (S.) Typhimurium uses its virulence factors to break colonization resistance through unknown mechanisms.
View Article and Find Full Text PDFIdentification of autophagy receptors for the Crohn's disease-associated adherent-invasive .
Front Cell Infect Microbiol
April 2024
Introduction: Crohn's disease (CD) is a chronic inflammatory bowel disease, of which the etiology involves genetic, environmental and microbial factors. Adherent-invasive (AIEC) and polymorphisms in autophagy-related genes have been implicated in CD etiology. Autophagy is a key process for the maintenance of cellular homeostasis, which allows the degradation of damaged cytoplasmic components and pathogens via lysosome.
View Article and Find Full Text PDFObjectives: The literature on vaccine hesitancy has widely commented on the various factors leading some to feel particularly at risk of disease infection while others do not. But little attention has been paid to whether we also see such differences regarding people's assessment of their personal vulnerability towards vaccine adverse events (AEs).
Methods: We designed two cross-sectional online surveys among representative samples of the French mainland population (n = 2015 and 3087).