[The optimization of the treatment of epilepsy with carbamazepine in puberty].

A study was made of the pharmacokinetics of carbamazepine (CBZ) in epileptic patients in the pubertal period. In a group of patients with fully controlled fits, the concentrations of CBZ ranged within the mean values of the therapeutic concentration. Meanwhile in a group with an incomplete therapeutic effect and without any effect, the mean dose of CBZ per kg weight was even higher than that in the group with fully controlled fits.

[Circulatory disorders in the vertebrobasilar system in the presence of Kimmerle's anomaly].

Patients belonging to different age groups, suffering from Kimmerle's abnormality (KA), manifested neurological symptoms caused by circulatory disturbances in the vertebral basilar system. KA is an extravasal factor in respect of the vertebral artery, causing a compression-stenosing-irritative effect.

[Characteristics of the clinical manifestations of mesofrontal epileptic seizures].

The patients with mesofrontal epilepsy (ME) were under this study. Idiopathic atrophic events in the cerebral cortex are the major etiology factors. ME seizures develop as a sequence of epileptic discharges in the supplementary motor zone (SMZ) and have some characteristic features as tonic convulsions in one or both hands with concomitant adversive spells, short seizures with prompt after-seizure orientation and the proprioceptive afferent signals being capable of provoking the spells.

[Hypothalamic syndromes after the administration of toxic doses of drugs for terminating pregnancy].

Twenty-five women presented with primary injuries of the hypothalamic area and the hypothalamic syndrome that resulted from the intake of toxic doses of drugs (TDD) for inducing an abortion. The situation was simulated in mature rats. Experiments evidenced a predominant involvement of the hypothalamic area, vs.