[Effect of lipopolysaccharide of the pseudotuberculosis bacterium on the functional activity of macrophages].

Study of the effect of lipopolysaccharide (LPS) of Y. pseudotuberculosis on the culture of peritoneal macrophages of guinea pigs has established that in concentrations of 1-10 micrograms/ml LPS stimulated the absorption and digestive activity of the macrophages. In concentrations of 50-100 micrograms/ml it had a cytotoxic effect on the cell elements and inhibited their phagocytic function.

[Enzymes of the detoxication of active forms of oxygen and lipoperoxides in experimental ischemia and myocardial infarct].

Variation in the activity of superoxide dismutase, glutathione peroxidase (tretbutyl hydroperoxide as a substrate) and glutathione-S-transferase (1-chloro-2,4-dinitrobenzene as a substrate) was studied in rat ischemia and in coronaro-occlusion myocardial infarction. The activity of superoxide dismutase and glutathione peroxidase drastically reduced 2-15 minutes after ligation of the coronary artery and remained at the decreased level during the observation period (14 days). The activity of glutathione-S-transferase in the infarcted zone of the myocardium significantly decreased only by day 3 of the experiment.

[Lipid level in sudden cardiac death (a biochemical and morphological study)].

The study covered 114 men dying suddenly of coronary heart disease (CHD). Hypercholesterinemia was found in 43% of the cases, lowered cholesterol, high density lipoproteins or hypoalphacholesterolemia in 75%. Thus hypoalphacholesterolemia correlates with CHD more frequently than hypercholesterolemia.