[Flow cytometry evaluation of the rhesus monkey cellular immunity following the Zaire ebolavirus (Filoviridae; Ebolavirus: Zaire ebolavirus) experimental infection].

Introduction: The outbreaks of the Zaire ebolavirus (ZE) disease (ZED) that have arisen in the last decade determine the need to study the infection pathogenesis, the formation of specific immunity forming as well as the development of effective preventive and therapeutic means. All stages of fight against the ZED spread require the experimental infection in sensitive laboratory animals, which are rhesus monkeys in case of this disease .The aim of the study is to evaluate the rhesus monkey cellular immunity following the ZE experimental infection by the means of flow cytometry (cytofluorimetry).

[Evaluation of the functional state of drivers by parameters of vegetative regulation of cardiac rhythm with the use of method of wireless cardiorhythmography].

Analysis of heart rate variability (HRV) provides the possibility to obtain the predictive and meaningful information on the functional status and features of adaptive responses of the whole organism. Monitoring the functional state in the course of professional activities with the use of wireless cardiorhythmography provides data acquisition on heart rate dynamics in accordance with the level of occupational load. The article is devoted to the development of methods for rapid assessment of the functional state of motor vehicle drivers in the process of occupational activity.

[Application of ultrasonographic investigation and computer tomography in diagnosis and the treatment method choice of complex postoperative hernias of the abdominal wall].

The work is based on analysis of the results of the abdominal hernia (AH) and the anterior abdominal wall state investigation in 48 patients of the main group and in 20--of a control one, using ultrasonographic examination (USE) and computer tomography (CT). The parameters of hernial localization, the hernial sac size and content, the hernial gates size and quantity, as well as the degenerative changes severity of the abdominal wall musculo-aponeurotic structures were investigated in the patients, suffering complex postoperative AH. Degenerative changes in the anterior abdominal wall musculo-aponeurotic structures, more pronounced in the patients older than 50 years, and also in the presence of large and giant AH, especially while their durable persistence, were revealed according to the USE and CT data obtained.

[Simulation of the disease caused by Hantaan virus in white mice by a complex of virological, biochemical, and hematological parameters].

The essence of studies was that the disease is simulated in 12-day albino mice subcutaneously infected with Hantaan virus, strain 76-118 in a dose of 10 LD50. As an efficiency index, the study of drugs uses major (death protection coefficient, mean animal lifetime) and auxiliary (virological: pathogen accumulation in the brain tissues of deceased animals) parameters, biochemical (the levels of creatinine, urea, alanine aminotransferase, aspartate aminotransferase, malonic dialdehyde), hematological (count of leukocytes, leukogram) ones; as well as interferon status (the levels of circulatory interferon, leukocytic production of alpha- and gamma-interferons). The procedure for simulating the disease caused by Hantaan virus on an experimental animal is used to choose effective drugs against the pathogen of hemorrhagic nephrosonephritis.