Molecular characterization of birch toti-like virus, a plant-associated member of the new family Orthototiviridae.

A novel totivirus, named "birch toti-like virus" (BTLV), was discovered in European white birch (Betula pendula) plants. The genome of BTLV is 4,967 nucleotides long and contains two overlapping open reading frames (ORFs) coding for the capsid protein (CP) and an RNA-dependent RNA-polymerase (RdRP). The encoded CP and RdRP proteins shared 46.

Toward an era of impact of digital contingency management in the treatment of substance use disorders.

Digital contingency management entails remote methods to obtain biochemical confirmation of drug status and provide desirable, tangible consequences contingent on abstinence. Advances in digital CM suggest that it may be on the cusp of making a public health impact. Specific advances include technological capabilities and affordability, companies that specialize in digital CM, policies and reimbursement models, and the increasing availability of resources related to CM.

Nutritional interventions for preventing and treating pressure ulcers.

Background: Pressure ulcers affect 10% of people in hospitals and older people are at highest risk. The correlation between nutritional intake and the development of pressure ulcers is suggested by several studies, but the results are inconsistent.

Objectives: To evaluate the effectiveness of enteral and parenteral nutrition on the prevention and treatment of pressure ulcers.

Reassessment of body mass indices.

The accuracy of body mass indices (BMIs), such as Quetelet's index, for the definition of obesity was investigated in a large sample of healthy humans. Two hundred thirteen women and 150 men with a wide spectrum of weights, heights, and ages underwent densitometric analysis for the determination of percent body fat (%BF). %BF was then contrasted with various well-established BMIs.