[Effect of antioxidants on endotoxicosis in experimental peritonitis].

The chronic experiments on dogs with a peritonitis model showed that drugs possessing antioxidant properties (vitamin E, dimephosphon, xymedone) are capable of decreasing the inflammatory phenomena in abdominal cavity and decreasing the expression of endogenous intoxication, as manifested by a decrease in the plasma toxicity and the content of average-molecular-weight peptides and lipid peroxidation products. The most pronounced positive effect was observed for xymedone. A certain correlation between the effects of antioxidants upon endotoxicosis and free-radical lipid peroxidation reactions was established.

[Use of heparin in the early post-traumatic period in burns and hemorrhage].

Experiments on dogs (n = 86) revealed that a combined injury led to marked disorders in the hemostasis, manifesting by third-degree syndrome of disseminated intravascular coagulation which develops as early as at the height of injury. Infusion therapy, particularly making use of intravenous polygluquin, led to progress of chronological and structural hypocoagulation and hypofibrinogenemia. Heparin in a dose of 25 to 30 U/kg b.