Publications by authors named "A N Goldstein-Piekarski"
The COVID-19 Pandemic increased the prevalence and severity of insomnia and depression symptoms. The effects of an insomnia intervention on future insomnia and depression symptoms delivered during an ongoing stressor, which may have precipitated the insomnia symptoms, is unknown. We conducted a two-arm randomized controlled pilot study to evaluate whether an insomnia intervention would improve the trajectory of insomnia and depression symptoms in the context of a global pandemic.
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- - Mechanistically targeted behavioral interventions, like problem-solving therapy, can improve depression outcomes by modifying neural circuits, which is especially essential for vulnerable groups with comorbid conditions such as obesity.
- - The study used functional magnetic resonance imaging to track cognitive control circuit activity in participants over 24 months, revealing that reduced activity in this circuit linked to better problem-solving skills and lower depression symptoms.
- - Changes in cognitive control circuit activity at 2 months were effective predictors for later improvements in problem-solving and depression, indicating a need for refining these circuit-based models for better clinical use.
Transdiagnostic Mood, Anxiety, and Trauma Symptom Factors in Alcohol Use Disorder: Neural Correlates Across 3 Brain Networks.
Biol Psychiatry Cogn Neurosci Neuroimaging
August 2024
Background: Alcohol use disorder (AUD) is associated with high rates of trauma, mood, and anxiety disorders. Across these diagnoses, individual symptoms substantially overlap, highlighting the need for a transdiagnostic approach. Furthermore, there is limited research on how transdiagnostic psychopathology impacts the neural correlates of AUD.
View Article and Find Full Text PDFNarcolepsy is a sleep disorder characterized by chronic and excessive daytime sleepiness, and sudden intrusion of sleep during wakefulness that can fall into two categories: type 1 and type 2. Type 1 narcolepsy in humans is widely believed to be caused as a result of loss of neurons in the brain that contain the key arousal neuropeptide Orexin (Orx; also known as Hypocretin). Patients with type 1 narcolepsy often also present with cataplexy, the sudden paralysis of voluntary muscles which is triggered by strong emotions (e.
View Article and Find Full Text PDFIt has long been thought that links between affect and sleep are bidirectional. However, few studies have directly assessed the relationships between: (1) pre-sleep affect and sleep electroencephalogram (EEG) activity; and (2) sleep EEG activity and post-sleep affect. This study aims to systematically explore the correlations between pre-/post-sleep affect and EEG activity during sleep.
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