Country data on AMR in Russia in the context of community-acquired respiratory tract infections: links between antibiotic susceptibility, local and international antibiotic prescribing guidelines, access to medicine and clinical outcome.

Background: Antimicrobial reistance (AMR) is one of the biggest threats to global public health. Selection of resistant bacteria is driven by inappropriate use of antibiotics, amongst other factors. COVID-19 may have exacerbated AMR due to unnecessary antibiotic prescribing.

Functional Analysis of the and Gene Variants Predicted to Affect Splicing.

It is estimated that up to one-third of all variants causing inherited diseases affect splicing; however, their deleterious effects and roles in disease pathogenesis are often not fully characterized. Given their prevalence and the development of various antisense-based splice-modulating approaches, pathogenic splicing variants have become an important object of genomic medicine. To improve the accuracy of variant interpretation in public mutation repositories, we applied the minigene splicing assay to study the effects of 24 variants that were predicted to affect normal splicing in the genes associated with propionic acidemia (PA)- and .

[The investigation into specific features of the distribution of carbofuran in the body of the warm-blooded animals].

The objective of the present study was to estimate the distribution of the carbamate pesticide carfbofuran in the organism of the warm-blooded animals (rats) after its intragastric administration. It was shown that large amounts of unmetabolized carbofuran were present in the internal organs and biological fluids. The highest content of carbofuran was recorded in the stomach, large and small intestines, testicles, urinary bladder, ureters, and heart.

[Evaluation of thrombocyte retractile activity using a retractograph].

Direct measurement of the force of clot contraction from the plasma in normal subjects and standardization of plasma platelet count, carried out with a retractograph, a newly designed apparatus, have helped assess the platelet retractile activity. Linear relationship between platelet count in the clot from the plasma and the force of the clot contraction, detected in normal subjects, allows one to do without standardization of the platelet count to a preset level when measuring the blood platelet retractile activity in patients.

[Polarographically active fraction of alpha 1-unstable glycoprotein in the blood serum during the malignant process].

The simple method of polarographical testing of the peripheral blood serum is recommended as a part of the complex cancer diagnosis for the evaluation of the effectivity of cancer treatment and for the mass preventive examination. This method modified by I. A.