Publications by authors named "A N Facundo"
Background/objectives: Approximately 25% of the world's population and more than 60% of patients with type 2 diabetes (T2D) have metabolic-dysfunction-associated steatotic liver disease (MASLD). The association between these pathologies is an important cause of morbidity and mortality in Brazil and worldwide due to the high frequency of advanced fibrosis and cirrhosis. The objective of this study was to determine the epidemiologic and clinical-laboratory profile of patients with T2D and MASLD treated at an endocrinology reference service in a state in northeastern Brazil, and to investigate the association of liver fibrosis with anthropometric and laboratory measurements.
View Article and Find Full Text PDFRelationship Between C-Peptide Levels, Clinical Features, and Serum Data in a Brazilian Type 1 Diabetes Population with Large Variations in Genomic Ancestry.
Int J Mol Sci
October 2024
Article Synopsis
- - Type 1 diabetes (T1D) is a chronic condition where the immune system attacks beta cells in the pancreas that produce insulin; C-peptide, released alongside insulin, is a helpful marker for evaluating pancreatic function due to its longer lifespan in the body.
- - A study involving 95 T1D patients focused on the levels of C-peptide and its relationship with factors like age, revealing that nearly 30% had some remaining insulin secretion, primarily linked to their age at diagnosis.
- - No significant differences were found in metabolic control or microvascular complications based on C-peptide levels, and it was noted that ancestry did not affect residual C-peptide function; future research should explore additional factors like HLA and pancreatic auto
The expression of and family genes in pituitary adenomas: clinical correlations and postsurgical outcomes.
Front Endocrinol (Lausanne)
October 2024
Introduction: Pituitary adenomas (PAs) are benign tumors with high prevalence and, occasionally, aggressive course. The tumorigenesis of these lesions is not completely understood at the molecular level. BAK1 and BAX proteins play fundamental roles in apoptosis and seem to interact with VDAC proteins, whose expressions have been markedly altered in cancer, impacting their prognosis.
View Article and Find Full Text PDFThe rewarding effects of drugs of abuse are associated with the dopaminergic system in the limbic circuitry. Nicotine exposure during adolescence is linked to increased use of drugs of abuse with nicotine and methamphetamine (METH) commonly used together. Nicotine acts on neuronal nicotinic acetylcholine receptor (nAChR) systems, critical for reward processing and drug reinforcement, while METH leads to a higher dopamine (DA) efflux in brain reward regions.
View Article and Find Full Text PDFArticle Synopsis
- A genetic variation (SNP rs2304297) in the 3' untranslated region of the human 6 gene affects how adolescent rats respond to nicotine in terms of movement, anxiety, and drug-seeking behavior.
- The study investigates how this SNP impacts dopamine and norepinephrine levels in key brain regions of both adolescent and adult rats, examining differences based on age, sex, and genetic background.
- Results indicate that male rats with the SNP show lower dopamine levels in the Nucleus Accumbens following drug-seeking behavior, suggesting the SNP is important for understanding the development of neurotransmitter systems related to nicotine addiction.