Emerging contaminants in polluted waters: Harnessing Biochar's potential for effective treatment.

Biochar is a carbon-rich, sponge-like material with intricate functionalities, making it suitable for various environmental remediation applications, including water treatment, soil amendment and, additives in construction materials, anaerobic digesters, and electrodes, among others. Its easy adaptability and low cost make it particularly attractive. This review highlights a range of biochar and surface-modified biochar exhibiting high uptake and degradation efficiencies for a broad spectrum of contaminants, including humic acid, disinfection by-products (DBPs), radioactive materials, dyes, heavy metals, antibiotics, microplastics, pathogens, Per- and polyfluoroalkyl substances (PFAS), and cytotoxins.

Glutathione peroxidase 4 overexpression induces anomalous subdiffusion and impairs glioblastoma cell growth.

Glioblastoma tumors are the most common and aggressive adult central nervous system malignancy. Nearly all patients experience disease progression, which significantly contributes to disease mortality. Recently, it has been suggested that recurrent tumors may be characterized by a ferroptosis-prone phenotype with a significant decrease in glutathione peroxidase 4 (GPx4) expression.

Late-Stage Reshaping of Phage-Displayed Libraries to Macrocyclic and Bicyclic Landscapes using a Multipurpose Linchpin.

Genetically encoded libraries (GEL) are increasingly being used for the discovery of ligands for "undruggable" targets that cannot be addressed with small molecules. Foundational GEL platforms like phage-, yeast-, ribosome-, and mRNA-display have enabled the display of libraries composed of 20 natural amino acids (20AA). Unnatural amino acids (UAA) and chemical post-translational modification (cPTM) expanded GEL beyond the 20AA space to yield unnatural linear, cyclic, and bicyclic peptides.

Iron promotes isocitrate dehydrogenase mutant glioma cell motility.

Enriched iron metabolic features such as high transferrin receptor (TfR) expression and high iron content are commonly observed in aggressive gliomas and can be associated with poor clinical responses. However, the underlying question of how iron contributes to tumor aggression remains elusive. Gliomas harboring isocitrate dehydrogenase (IDH) mutations account for a high percentage (>70 %) of recurrent tumors and cells with an acquired IDH mutation have been reported to have increased motility and invasion.