Publications by authors named "A N Boyden"
Background: Single-use anaesthetic drug trays are used widely in Australia, but their environmental impact is unclear.
Methods: A life cycle assessment was completed for 10 different types of single-use anaesthetic drug trays made of four materials: the synthetic plastics polypropylene and polystyrene, and the natural fibres bagasse (sugarcane pulp) and cellulose pulp.
Results: Carbon emissions per tray from total life cycle with landfill disposal were 33-454 g CO-eq, which equates to 152-2066 tonnes CO-eq annually.
Article Synopsis
- B cells play a crucial role in multiple sclerosis, highlighted by the effectiveness of therapies that deplete B cells, but their exact contribution to the disease is still not fully understood.
- This study used a specific mouse model of autoimmune encephalomyelitis to show that depleting B cells reduces disease progression and T cell activation related to a myelin protein.
- The researchers found that B cells are essential for presenting antigens to CD4 T cells, which is key in causing the disease, suggesting that understanding these interactions can help develop new treatments for autoimmune diseases.
Article Synopsis
- Intravascular perfusion with tissue fixatives is crucial in neuroscience to minimize artifacts during the handling of sensitive central nervous system tissues, with 10% NBF and 4% PFA commonly used.
- The study compared the effects of these two fixatives on handling artifacts and neurodegenerative changes in mice with experimental autoimmune encephalitis (EAE), finding that NBF-perfused animals had fewer severe dark neuron artifacts than those perfused with PFA.
- Results showed that while immersion fixation led to higher artifact scores, both NBF and PFA perfusion methods were equally effective for histopathological analysis in the EAE model.
Multiple sclerosis (MS) is an immune-mediated demyelinating disease of the CNS. We have previously demonstrated that CNS-specific CD8 T cells possess a disease-suppressive function in MS and variations of its animal model, experimental autoimmune encephalomyelitis (EAE), including the highly clinically relevant relapsing-remitting EAE disease course. Regulatory CD8 T cell subsets have been identified in EAE and other autoimmune diseases, but studies vary in defining phenotypic properties of these cells.
View Article and Find Full Text PDFInvestigating the complex cellular interplay controlling immunopathogenic and immunoregulatory responses is critical for understanding multiple sclerosis (MS) and for developing successful immunotherapies. Our group has demonstrated that CNS myelin-specific CD8 T cells unexpectedly harbor immune regulatory capacity in both mouse and human. In particular, PLP-specific CD8 T cells (PLP-CD8) robustly suppress the MS mouse model experimental autoimmune encephalomyelitis.
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