[Modulation of the M-cholinergic reaction by the venom of the Central Asian cobra (Naja naja oxiana)].

The effect of the Central Asian cobra's (Naja naja oxiana) poison upon cholinergic response of isolated small intestine was studied in the Wistar rats. The effect involved a significant activation by 30-70 per cent of M-cholinergic response in the type of "noncompetitive" interaction. The modulating effect of the poison is supposed to occur due to changes in cytoplasmatic membrane.

[Use of Naja oxiana venom for modulating the adrenergic process].

Specific changes of adrenergic responses to the poison of the Middle Asia cobra were found in the rat isolated small intestine. The changes reminded the action of inhibitors upon enzymes and may be characterized as a partial competitiveless interaction. The poison modulating effect upon adrenergic responses seem to be unrelated to its direct action on adrenoreceptors, but mediated through the effector cell's membrane.