Publications by authors named "A N Balan"
Background: Illness severity, comorbidity, fever, age and symptom duration influence antibiotic prescribing for respiratory tract infections (RTI). Non-medical determinants, such as patient expectations, also impact prescribing.
Aim: To quantify the effect of general practitioners' (GPs') perception of a patient request for antibiotics on antibiotic prescribing for RTI and investigate effect modification by medical determinants and country.
Article Synopsis
- The classification of the Millettieae group, particularly the Millettia genus with around 150 species, has been challenging and is shown to be polyphyletic based on new molecular evidence.
- This study utilized genome sequencing to clarify relationships within Millettieae, revealing three distinct subclades in Asian Millettia and proposing a narrower definition of the genus, while also reinstating two other genera, Pongamia and Otosema.
- Findings highlighted that African Millettia species are distinctly different from Asian ones and that the rapid diversification of these plants during the Mid-Miocene Climatic Optimum may contribute to their complex classification issues.
SpliceMutr shows that splicing antigenicity changes in response to ICI therapies and that native modulation of the splicing machinery through mutations increases the contribution of splicing to the neoantigen load of some The Cancer Genome Atlas cancer subtypes. Future studies of the relationship between splicing antigenicity and immune checkpoint inhibitor response pan-cancer are essential to establish the interplay between antigen heterogeneity and immunotherapy regimen on patient response.
View Article and Find Full Text PDFVaccination has played a critical role in mitigating COVID-19. Despite the availability of licensed vaccines, there remains a pressing need for improved vaccine platforms that provide high protection, safety, and versatility, while also reducing vaccine costs. In response to these challenges, our aim is to create a self-adjuvanted vaccine against SARS-CoV-2, utilizing Virus-Like Particles (VLPs) as the foundation.
View Article and Find Full Text PDFThe role of the iron-sulfur [Fe-S] cluster transcriptional regulator IscR in maintaining [Fe-S] homeostasis in bacteria is still poorly characterized in many groups. and other Alphaproteobacteria have a single operon encoding [Fe-S] cluster biosynthesis enzymes. We showed that the expression of this operon increases in iron starvation, but not in oxidative stress, and is controlled mainly by IscR.
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