Publications by authors named "A N Angelov"
Actinobacteria have frequently been reported in the Andean Puna, including strains of the genus Micrococcus. These strains demonstrate resistance to high levels of UV radiation, arsenic, and multiple antibiotics, and possess large linear plasmids. A comparative analysis of the sequences and putative functions of these plasmids was conducted.
View Article and Find Full Text PDFAutoimmune diseases represent a severe personal and healthcare problem that seeks novel therapeutic solutions. Mesenchymal stem cells (MSCs) are multipotent cells with interesting cell biology and promising therapeutic potential. The immunoregulatory effects of secretory factors produced by umbilical cord mesenchymal stem cells (UC-MSCs) were assessed on B lymphocytes from 17 patients with systemic lupus erythematosus (SLE), as defined by the 2019 European Alliance of Associations for Rheumatology (EULAR)/American College of Rheumatology (ACR) classification criteria for SLE, and 10 healthy volunteers (HVs).
View Article and Find Full Text PDFWe have used multiple sequencing approaches to sequence the genome of a volunteer from Saudi Arabia. We use the resulting data to generate a de novo assembly of the genome, and use different computational approaches to refine the assembly. As a consequence, we provide a contiguous assembly of the complete genome of an individual from Saudi Arabia for all chromosomes except chromosome Y, and label this assembly KSA001.
View Article and Find Full Text PDFObjectives: Despite extensive public health initiatives, Bulgaria still has the lowest life expectancy at birth (LE) in the European Union. Sex and ethnic differences in LE and mortality are also exceptionally large. We aimed to identify what causes of death drive these wide disparities and thus provide clear targets for future public health interventions.
View Article and Find Full Text PDFArticle Synopsis
- Ankylosing Spondylitis (AS) is a chronic inflammatory arthritis linked to higher cardiovascular risks, primarily due to accelerated atherosclerosis, although some studies show mixed results regarding this association.
- Endothelial dysfunction, common in AS patients, amplifies the effects of inflammation and traditional cardiovascular risk factors, potentially speeding up artery damage before other vascular issues arise.
- Investigations suggest key factors like adhesion molecules can predict cardiovascular events, and treatments such as angiotensin receptor blockers and statins might lower cardiovascular risks in AS patients, highlighting the need for further studies.