Publications by authors named "A N Akarsu"
Article Synopsis
- PI3K is involved in immune function, and defects in the PI3K/AKT/mTOR pathway lead to issues like recurrent infections, autoimmunity, and abnormal immune cell proliferation.
- The study analyzed 12 patients with different PIK3 variants, revealing a long diagnostic delay and common symptoms such as respiratory infections and autoimmune issues in those with activated PI3K delta syndrome (APDS).
- Molecular genetic analysis is essential for accurate diagnosis of these immune defects, as laboratory findings can help distinguish between APDS and other conditions related to immune dysregulation.
Background: The COVID-19 pandemic has caused significant morbidity and mortality globally. The role of plasma-derived extracellular vesicles (EVs) in pediatric COVID-19 patients remains unclear.
Methods: We isolated EVs from healthy controls (n = 13) and pediatric COVID-19 patients (n = 104) with varying severity during acute and convalescent phases using serial ultracentrifugation.
Background: Optimum management of food allergy (FA) includes consideration of co-allergies and multimorbidities and tolerance assessment. Documentation of FA practices may pave the way for better practice.
Methods: Patients aged 3-18 years, with persistent IgE-mediated hen`s egg allergy were reviewed.
Isotype class-switch recombination (CSR), somatic hypermutation (SHM), B cell signalling and DNA repair mechanisms defects are responsible for high IgM. The hyperimmunoglobulin M (HIGM) phenotype and CSR-related defects are now classified under primary antibody defects, combined immunodeficiencies or syndromic immunodeficiencies groups. The aim of the study is to evaluate the diverse phenotypic/genotypic/laboratory characteristics and outcome of patients with CSR defects and HIGM-related defects.
View Article and Find Full Text PDFExploring the Heterogeneity of IgE-Mediated Food Allergy through Latent Class Analysis.
Int Arch Allergy Immunol
March 2023
Introduction: Food allergy (FA) is a heterogeneous disease with multiple morbidities and a huge burden for patients and healthcare systems. Variable manifestations, comorbidities (atopic dermatitis [AD], asthma, and/or allergic rhinitis [AR]), severity (anaphylaxis), and outcomes suggest the existence of different endotypes that cluster analyses may reveal. In this study, we aimed to investigate distinct subgroups among patients with FAs using data from 524 children/adolescents.
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