Publications by authors named "A Mutarelli"
Article Synopsis
- Acute rheumatic fever (ARF) leads to serious long-term health issues, particularly chronic rheumatic heart disease, which affects heart valves.
- The majority of ARF cases (over 80%) occur in low- and middle-income countries, indicating a strong link between this disease and socioeconomic factors.
- Understanding the clinical, genetic, and sociodemographic risk factors of ARF can help healthcare providers identify those at high risk and implement better management and screening strategies to improve patient outcomes.
A 28-year-old woman, gravida 2 para 1, with previously unknown severe rheumatic mitral stenosis presented with progressive dyspnea at 26 weeks of gestation. Percutaneous commissurotomy was considered but was deferred after symptom improvement with beta-blockers and diuretics. Pregnancy complications ensued, requiring preterm delivery.
View Article and Find Full Text PDFIntroduction: Tirofiban is a fast-acting glycoprotein IIb-IIIa inhibitor that inhibits the final common pathway to platelet aggregation and has been studied as adjuvant therapy for acute ischemic stroke (AIS). Since the prior meta-analysis new randomized controlled trials (RCTs) have been published. This meta-analysis aimed to update the current knowledge on the efficacy of tirofiban for patients with AIS not submitted to reperfusion therapies.
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- * From 517 enrolled patients, stroke incidence was measured at 3.0 per 100 patient-years, with factors like age, left atrial volume, and left ventricular ejection fraction (LVEF) identified as key predictors.
- * The study noted a complex relationship between stroke risk and heart function, particularly a threshold LVEF of 45%, leading to improved prediction models for stroke risk in this patient group.
The efficacy and safety of direct oral anticoagulants (DOAC) in patients with embolic stroke of undetermined source (ESUS) remains unclear. We systematically searched PubMed, Embase, and Cochrane Library for randomized controlled trials (RCT) comparing DOACs versus aspirin in patients with ESUS. Risk ratios (RR) and 95% confidence intervals (CI) were computed for binary endpoints.
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