Publications by authors named "A Mujica"
Pain is a morbidity or comorbidity with a high incidence that significantly impacts the well-being of patients. In this study, we evaluated the effects of systemic administration of tramadol, a weak mu-opioid receptor (MOR) agonist, plus quinpirole (a D2-like receptor agonist). The study was performed in naïve rats and in rats with induced inflammatory and neuropathic pain.
View Article and Find Full Text PDFThe Andean kañihua seed ( Aellen) is widely used as an ancestral nutraceutical with great industrial potential and is a little-researched seed. It has high biological and nutritional value due to its protein content of 15-19 %, optimal balance of essential amino acids, essential fatty acids, mineral content, vitamins, and non-bitter saponin content. It is a potential source of peptides with different pharmacological activities such as antimicrobials, antioxidants, antihypertensives, and antidiabetics, among others.
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- The study explores the link between a repeated genetic sequence (G4C2) in the C9orf72 gene and conditions like familial ALS and FTD.
- Researchers created a new mouse model with 96 copies of the G4C2 repeat to better understand how these repeats can become unstable over generations.
- Two main mechanisms were identified for repeat expansion: minor increases due to a mismatch repair pathway and larger expansions triggered by DNA breaks, with implications for understanding the genetic instability seen in human cases.
High-Pressure Behavior of CaSnO, SrSnO, and ZnSnO.
J Phys Chem C Nanomater Interfaces
January 2024
Article Synopsis
- The study examined the structural changes in CaSnO, SrSnO, and ZnSnO under high pressure using powder X-ray diffraction and density functional theory up to 20 GPa.
- No phase transitions were observed in CaSnO and ZnSnO, while SrSnO exhibited a transition at 9.09 GPa from a tetragonal polymorph to a different tetragonal form.
- The research also provides detailed data on the compressibility, pressure-volume equations, elastic constants, and high-pressure behavior of these compounds, contributing to the understanding of MSnO stannates.
Rats were more frequently used than mice to model human disease before mouse embryonic stem cells (mESCs) revolutionized genetic engineering in mice. Rat ESCs (rESCs) were first reported over 10 years ago, yet they are not as frequently used as mESCs. CRISPR-based gene editing in zygotes is widely used in rats but is limited by the difficulty of inserting or replacing DNA sequences larger than about 10 kb.
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