Publications by authors named "A Mujal"
Natural Killer (NK) cells are innate cytotoxic lymphocytes that possess features of adaptive immunity, including antigen specificity and clonal expansion. NK cells rapidly respond to cytokines released during the innate phase of viral infection and are thought to migrate from circulation into infected organs to execute their early effector functions. However, recent evidence suggests that tissue-resident NK cells are among the first responders to viral infection.
View Article and Find Full Text PDFMetastasis frequently develops from disseminated cancer cells that remain dormant after the apparently successful treatment of a primary tumour. These cells fluctuate between an immune-evasive quiescent state and a proliferative state liable to immune-mediated elimination. Little is known about the clearing of reawakened metastatic cells and how this process could be therapeutically activated to eliminate residual disease in patients.
View Article and Find Full Text PDFArticle Synopsis
- The tumor immune microenvironment (TIME) is made up of various myeloid cells that show complex identities and behaviors, making it hard to understand their role in T-cell function and patient outcomes.
- Researchers used single-cell RNA-sequencing to analyze mouse and human tumors, discovering that the diversity of monocyte-macrophage cells is influenced by both lineage and transcriptional changes during their development.
- In mice, the transformation from monocytes to macrophages was linked to the presence of regulatory T cells (Tregs), while in human kidney cancer, variations in macrophage types and myeloid cell makeup correlated with the density of Tregs and the effectiveness of CD8+ T cells.
Natural killer (NK) cells are innate lymphocytes that provide critical host defense against pathogens and cancer. Originally heralded for their early and rapid effector activity, NK cells have been recognized over the last decade for their ability to undergo adaptive immune processes, including antigen-driven clonal expansion and generation of long-lived memory. This review presents an overview of how NK cells lithely partake in both innate and adaptive responses and how this versatility is manifest in human NK cell-mediated immunity.
View Article and Find Full Text PDFArticle Synopsis
- Multiphoton microscopy is a cool imaging technique that helps scientists see inside tissues without damaging them, but it needs careful adjustments to work well.
- Researchers created a smart method that automatically changes how much light is used based on the shape of the sample, making it easier to see important details without special staining.
- By using this method, they could observe how immune cells behave in mouse lymph nodes after vaccination, discovering new information about T cells and their movement during the immune response.