Publications by authors named "A Mughal"

Robotic-assisted thoracic surgery has become increasingly utilized in recent years. Complex lung cancer resection surgery can be performed using a robotic approach. It facilitates 3-dimentional visualization of structures, enhanced manipulation of tissues and precise movements.

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Background/aims: Amitriptyline is prescribed off-label for irritable bowel syndrome (IBS). We conducted a meta-analysis to assess its efficacy.

Methods: A systematic literature review was conducted until November 10, 2023, using MEDLINE, Embase, Cochrane Library, and Web of Science to study the efficacy of amitriptyline in patients with IBS.

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Polychlorinated biphenyls (PCBs) are persistent organic pollutants and are emitted during e-waste activities. Once they enter into the environment, PCBs could pose toxic effects to environmental compartments and public health. Reductive dechlorination offers a sustainable solution to manage the PCBs-contaminated environment.

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The routing of blood flow throughout the brain vasculature is precisely controlled by mechanisms that serve to maintain a fine balance between local neuronal demands and vascular supply of nutrients. We recently identified two capillary endothelial cell (cEC)-based mechanisms that control cerebral blood flow in vivo: 1) electrical signaling, mediated by extracellular K-dependent activation of strong inward rectifying K (Kir2.1) channels, which are steeply activated by hyperpolarization and thus are capable of cell-to-cell propagation, and 2) calcium (Ca) signaling, which reflects release of Ca via the inositol 1,4,5-trisphosphate receptor (IPR)-a target of G-protein-coupled receptor signaling.

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Article Synopsis
  • * GACI is a rare disease that results in significant arterial calcification, often leading to conditions like heart failure and pulmonary stenosis.
  • * A study identified a new pathogenic variant in ENPP1 from a Pakistani family, linked to severe valvular pulmonary stenosis, confirming its role in GACI through genetic analysis and functional studies.
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