Exploring long-term outcomes following CyberKnife robotic radiosurgery for trigeminal neuralgia.

Background And Purpose: Radiosurgery has been extensively studied for its efficacy and safety in the management of trigeminal neuralgia (TN). However, among the plethora of relevant studies in the literature, only a restricted number have been conducted targeting an elongated trigeminal nerve segment with the CyberKnife radiosurgery (CKRS) system. Herein, we report long-term clinical outcomes of TN patients treated with CKRS.

Spatial distribution of the imaging dose and characterization of the scatter radiation contribution in CyberKnife radiosurgery.

Purpose: The imaging dose for intra- and extra-cranial CyberKnife radiosurgery applications was calculated and the scattered radiation reaching the digital detectors was quantified and analyzed with regard to its origin.

Methods: The image guidance subsystem of the CyberKnife was modeled based on vendor-provided information. The emitted X-ray energy spectrum for 120 kV was estimated using the SpekPy software tool.

On the effect of dose delivery temporal domain on the biological effectiveness of central nervous system CyberKnife radiosurgery applications: theoretical assessment using the concept of biologically effective dose.

The diversity in technical configuration between clinically available radiosurgery systems, results in accordingly diverse treatment times for the same physical dose prescription, spanning from several min to more than 1 h. This, combined with evidence supporting the impact of dose delivery temporal pattern on the bio-effectiveness of low-LET radiation treatments, challenges the 'acute exposure' assumption adopted clinically to estimate the biological outcome of a given treatment scheme under the concept of biologically effective dose (BED).: In this work, the treatment plans of 30 patients underwent CyberKnife radiosurgery for vestibular schwannoma (VS), prescribing a marginal dose of 13 Gy to the tumor, were retrospectively reviewed and the corresponding dose distributions were resolved in the temporal domain.

Assessing the dose rate delivery of helical TomoTherapy prostate and head & neck treatments.

The dose rate distributions delivered to 55 prostate and head & neck (H&N) cancer patients treated with a helical TomoTherapy (HT) system were resolved and assessed with regard to pitch and field width defined during treatment planning. Statistical analysis of the studied cases showed that the median treatment delivery time was 4.4 min and 6.

On the total system error of a robotic radiosurgery system: phantom measurements, clinical evaluation and long-term analysis.

The total system error (TSE) of a CyberKnife system was measured using two phantom-based methods and one patient-based method. The standard radiochromic film (RCF) end-to-end (E2E) test using an anthropomorphic head and neck phantom and isocentric treatment delivery was used with the 6Dskull, Fiducial and Xsight spine (XST) tracking methods. More than 200 RCF-based E2E results covering the period from installation in 2006 until 2017 were analyzed with respect to tracking method, system hardware and software versions, secondary collimation system, and years since installation.