Publications by authors named "A Morinaga"
Article Synopsis
- Amyotrophic lateral sclerosis (ALS) is a serious neurodegenerative disease, and recent research reveals the Src/c-Abl inhibitor, bosutinib, as a promising candidate for treatment after a phase 1 study showed it to be safe for ALS patients.
- The ongoing phase 2 study aims to assess bosutinib's efficacy and long-term safety over a 24-week treatment period, with 25 ALS patients participating and receiving either 200 mg or 300 mg doses.
- The study has ethical approval from multiple universities and plans to share its findings in peer-reviewed journals and scientific conferences.
Article Synopsis
- The study focused on the concealed nodoventricular/nodofascicular (NV/NF) pathway, which is a connection involved in a type of heart rhythm disorder known as atrioventricular nodal reentrant tachycardia (AVNRT).
- Researchers analyzed 101 patients who underwent catheter ablation for AVNRT, finding that 3% had this bystander NV/NF pathway associated with different types of AVNRT.
- The study revealed a unique two-phase resetting response in AVNRT when using ventricular extra-stimuli (VES) and ventricular overdrive pacing (VOP), indicating different effects depending on the timing of these interventions.
Understanding the effect of noncovalent interactions of intermediates at the polarized catalyst-electrolyte interface on water oxidation kinetics is key for designing more active and stable electrocatalysts. Here, we combine optical spectroscopy, X-ray absorption spectroscopy (XAS), and surface-enhanced infrared absorption spectroscopy (SEIRAS) to probe the effect of noncovalent interactions on the oxygen evolution reaction (OER) activity of IrO in acidic and alkaline electrolytes. Our results suggest that the active species for the OER (Ir-*O) binds much stronger in alkaline compared with acid at low coverage, while the repulsive interactions between these species are higher in alkaline electrolytes.
View Article and Find Full Text PDFIn this study, we aimed to separately evaluate the relationship between waist circumference and the incidence of hyperuricemia in men and women in the general Japanese population. We performed a population-based longitudinal study using data from the annual health examination of residents of Iki City, Japan. A total of 5567 participants without hyperuricemia at baseline were included in the analysis.
View Article and Find Full Text PDFObjective: We aimed to clarify the relationship between serum alanine transaminase (ALT) levels and incidence of new-onset diabetes in a Japanese general population.
Setting: Population-based retrospective cohort study using annual health check-up data for residents of Iki City, Nagasaki Prefecture, Japan.
Participants: A total of 5330 Japanese individuals (≥30 years old) without diabetes at baseline were analysed.