Publications by authors named "A Morimoto"
Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis (EBV-HLH) has a wide range of clinical presentations and is sometimes life-threatening. It is often treated with systemic corticosteroids and etoposide, but no optimal treatment has been identified. Dexamethasone palmitate (DP) contains a combination of dexamethasone and a lipid emulsion and is selectively taken up by activated macrophages.
View Article and Find Full Text PDFBackground: To establish simple screening tests to suspect Alzheimer's disease (AD) pathology, the clinical sign "head-turning sign" (HTS), which is a patient's behavior of turning their head towards their partner to seek assistance with questions posed by the examiner during the interview, and the simple screening questionnaire for dementia named "Neucop-Q" were validated in participants diagnosed with amyloid and tau positron emission tomography (PET).
Methods: We enrolled 155 patients: 47 cognitive normal, 36 with mild cognitive impairment, 64 with dementia, and 8 with psychiatric disorders. All participants underwent Neucop-Q [three questions: Consciousness/self-awareness of cognitive disabilities (C) normal/impaired (nor/imp), Pleasure/pastime (P) nor/imp, and News/knowledge on current topics (N) nor/imp] and amyloid/tau PET.
Introduction: Individual preparedness for large-scale earthquakes is essential for safety and security in Japan, where earthquakes frequently occur. Foreign residents in Japan face barriers to gathering disaster information, and international students are likely to be more vulnerable to the effects of earthquakes due to the shorter duration of their stay in Japan. However, no studies have been conducted on international students' individual preparedness for large-scale earthquakes in Japan.
View Article and Find Full Text PDFArticle Synopsis
- * In adults, LCH can present with lung lesions that improve with smoking cessation, but most cases require aggressive treatment similar to pediatric cases, with new targeted molecular therapies offering hope for severe cases.
- * Over 30% of multisystem LCH cases recur, leading to long-term complications such as central diabetes insipidus and neurodegenerative disorders, highlighting the need for improved therapeutic strategies to manage these unique challenges.
Study Question: Is oocyte developmental competence associated with changes in granulosa cell (GC) metabolism?
Summary Answer: GC metabolism is regulated by the LH surge, altered by obesity and reproductive aging, and, in women, specific metabolic profiles are associated with failed fertilization versus increased blastocyst development.
What Is Known Already: The cellular environment in which an oocyte matures is critical to its future developmental competence. Metabolism is emerging as a potentially important factor; however, relative energy production profiles between GCs and cumulus cells and their use of differential substrates under normal in vivo ovulatory conditions are not well understood.