The Internet of Things generates vast data volumes via diverse sensors, yet its potential remains unexploited for innovative data-driven products and services. Limitations arise from sensor-dependent data handling by manufacturers and user companies, hindering third-party access and comprehension. Initiatives like the European Data Act aim to enable high-quality access to sensor-generated data by regulating accuracy, completeness, and relevance while respecting intellectual property rights.
View Article and Find Full Text PDFThe knee meniscus distributes and dampens mechanical loads. It is composed of water (∼70%) and a porous fibrous matrix (∼30%) with a central core that is reinforced by circumferential collagen fibers enclosed by mesh-like superficial tibial and femoral layers. Daily loading activities produce mechanical tensile loads which are transferred through and dissipated by the meniscus.
View Article and Find Full Text PDFObjective: Knee meniscus tissue is partly vascularized, meaning that nutrients must be transported through the extracellular matrix of the avascular portion to reach resident cells. Similarly, drugs used as therapeutic agents to treat meniscal pathologies rely on transport through the tissue. The driving force of diffusive transport is the gradient of concentration, which depends on molecular solubility.
View Article and Find Full Text PDFDamage to the meniscus has been associated with excessive shear loads. Aimed at elucidating meniscus pathophysiology, previous studies have investigated the shear properties of the meniscus fibrocartilaginous core. However, the meniscus is structurally inhomogeneous, with an external cartilaginous envelope (tibial and femoral surface layers) wrapping the tissue core.
View Article and Find Full Text PDFDue to lack of full vascularization, the meniscus relies on diffusion through the extracellular matrix to deliver small (e.g., nutrients) and large (e.
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