The carbonyl nucleobase adduct MAde is a potent antigen for adaptive polyclonal MR1-restricted T cells.

The major histocompatibility complex (MHC) class I-related molecule MHC-class-I-related protein 1 (MR1) presents metabolites to distinct MR1-restricted T cell subsets, including mucosal-associated invariant T (MAIT) and MR1T cells. However, self-reactive MR1T cells and the nature of recognized antigens remain underexplored. Here, we report a cell endogenous carbonyl adduct of adenine (8-(9H-purin-6-yl)-2-oxa-8-azabicyclo[3.

Factors affecting inflammatory changes in congenital lung malformations.

Aim Of The Study: Patients with congenital lung malformation (CLM) may present pulmonary inflammatory changes. However, little is known about the factors influencing local inflammation. The aim of this study was to evaluate the factors that may affect inflammatory changes in CLM.

Main genetic entities associated with tooth agenesis.

Background: Tooth agenesis refers to the absence of one or more of the deciduous or permanent teeth. Tooth agenesis results from a series of disrupted reciprocal ectodermal mesenchymal interactions taking place during the early stages of tooth development.

Methods: A narrative literature review was performed to describe the main genetic syndromes associated with tooth agenesis.

Design and implementation of the first proton beam transport line in VEGA-3 Petawatt laser system.

Laser-Plasma ion acceleration is acquiring importance on a daily basis due to incipient applicability in certain research fields. However, the energy and divergence control of these brilliant sources can be considered a bottleneck in the development of some applications. In this work, we present the commissioning of a compact proton beamline based on a triplet of quadrupoles dedicated to focus and collect short and energetic pulses, open to the user community.