Publications by authors named "A Mooney"

Article Synopsis
  • Non-pharmacological interventions could improve quality of life for individuals with primary progressive aphasia (PPA) and their caregivers but need more efficacy trials.
  • The Communication Bridge-2 (CB2) trial is the first international, video chat-based randomized controlled trial focusing on speech-language interventions for PPA.
  • The trial successfully recruited and randomized 95 participant dyads across four countries, demonstrating that global recruitment for non-drug trials in this field is feasible and may serve as a model for future research in Alzheimer's and related dementias.
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Introduction: Interventions to treat speech-language difficulties in primary progressive aphasia (PPA) often use word accuracy as a highly comparable outcome. However, there are more constructs of importance to people with PPA that have received less attention.

Methods: Following Core Outcome Set Standards for Development Recommendations (COSSTAD), this study comprised: Stage 1 - systematic review to identify measures; Stage 2 - consensus groups to identify important outcome constructs for people with PPA (n = 82) and care partners (n = 91); Stage 3 - e-Delphi consensus with 57 researchers.

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Since its establishment in 1997, the US Department of Defense (DoD) Global Emerging Infections Surveillance (GEIS) program has provided support for infectious disease pandemic preparedness and response. The GEIS program has shown the value of having a central hub responsible for coordinating a global network of DoD laboratories that conduct surveillance for militarily relevant infectious disease threats. The program has supported the establishment and maintenance of capabilities for collecting, characterizing, and reporting on major infectious disease events, including the COVID-19 pandemic and mpox outbreak.

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Article Synopsis
  • - Trauma can lead to mental health issues like PTSD, depression, and anxiety, creating a need for new treatments that address both barriers to care and the biological aspects of these conditions.
  • - A clinical trial tested the effects of a 4-week morning light treatment on individuals with traumatic stress, using different durations (15, 30, or 60 minutes) to see its impact on the brain and emotional symptoms.
  • - Results showed a decrease in right amygdala reactivity for those in the 30 and 60 min groups, and all participants experienced reduced clinical symptoms, particularly those in the 60 min group, indicating that morning light treatment may be a promising option for addressing traumatic stress.
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Article Synopsis
  • This study outlines the creation of the first tool specifically designed for assessing functional communication in individuals with primary progressive aphasia (PPA), with plans to adapt it for other progressive illnesses.
  • The protocol emphasizes the need for a validated and reliable method to evaluate communication abilities that minimizes the burden on patients and focuses on their strengths.
  • The lack of existing strengths-based assessment tools for PPA highlights a critical gap in both clinical practice and research, which this study aims to fill.
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