The Complex Connection Between Myocardial Dysfunction and Cancer Beyond Cardiotoxicity: Shared Risk Factors and Common Molecular Pathways.

Cardiovascular diseases and cancer represent the largest disease burden worldwide. Previously, these two conditions were considered independent, except in terms of cardiotoxicity, which links cancer treatment to subsequent cardiovascular issues. However, recent studies suggest that there are further connections between cancer and heart disease beyond cardiotoxicity.

Development of a Simple IFN-γ Release Whole Blood Assay for the Assessment of Specific Cellular Immunity in Dogs.

Canine leishmaniosis (CanL) is a zoonotic disease caused by , where increased interferon-gamma (IFN-γ) levels are associated with controlling the infection and mild to moderate disease. Therefore, monitoring IFN-γ concentrations is essential for monitoring the immune responses in CanL. This study compared a faster, cost-effective IFN-γ release whole blood assay in tubes (WBA-T) with a standardized version (WBA-S) in 41 dogs at different states of infection.

Randomized Trials Using Provincial Health Numbers for Group Assignment.

Purpose: Using data from Ontario, Canada, this report shows how provincial government-assigned health card numbers can be used for individual-level randomization in large pragmatic trials. We describe how health card numbers are assigned and analyze the distribution of health card digits in a trial setting. We then provide an example of how they can be used for randomization and discuss the methodological and practical considerations of the approach.

Toward Improving Human Training by Combining Wearable Full-Body IoT Sensors and Machine Learning.

This paper proposes DigitalUpSkilling, a novel IoT- and AI-based framework for improving and personalising the training of workers who are involved in physical-labour-intensive jobs. DigitalUpSkilling uses wearable IoT sensors to observe how individuals perform work activities. Such sensor observations are continuously processed to synthesise an avatar-like kinematic model for each worker who is being trained, referred to as the worker's digital twins.