Publications by authors named "A Moisan"
Article Synopsis
- A study conducted in France during the 2023-24 RSV season analyzed the effectiveness of nirsevimab, a monoclonal antibody, in preventing RSV infections in infants, focusing on breakthrough cases.
- Out of 695 RSV-infected infants, researchers sequenced the full-length RSV genome of 545 infants, identifying that 48% had breakthrough infections despite receiving nirsevimab.
- While no resistance was found in RSV-A infections from nirsevimab-treated infants, two cases of RSV-B showed substitutions linked to resistance, indicating a potential concern for the antibody's effectiveness against this variant.
Article Synopsis
- - Clubfoot is a common birth defect affecting 1 in 1000 babies, and the Ponseti method is a widely used treatment involving manipulation, casting, and orthotic use, but many patients face issues with recurrence of the deformity.
- - A study tracked 127 clubfoot patients from 2010 to 2014, assessing caregivers' experiences with the Ponseti method through questionnaires, focusing on their beliefs about the necessity and use of braces.
- - Results indicated that caregivers who doubted the need for braces or felt uncomfortable using them were significantly more likely to experience treatment failure, highlighting the importance of addressing caregiver concerns to improve treatment outcomes.
98% of T cells reside in tissues, yet nearly all human T cell analyses are performed from peripheral blood. We single-cell sequenced 5.7 million T cells from ten donors' autologous blood and tonsils and sought to answer key questions about T cell receptor biology previously unanswerable by smaller-scale experiments.
View Article and Find Full Text PDFBackground: Congenital talipes equinovarus, or clubfoot, can lead to lifelong functional impairments, including diminished gross motor skills (GMS), if left untreated. The Ponseti method corrects idiopathic clubfoot through casting and bracing. Given the importance of GMS in childhood development, this technique must be optimized to support childhood and long-term health outcomes.
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