The crystal structures determination and Hirshfeld surface analysis of -(4-bromo-3-meth-oxy-phen-yl)- and -{[3-bromo-1-(phenyl-sulfon-yl)-1-indol-2-yl]meth-yl}- derivatives of -{[3-bromo-1-(phenylsulfon-yl)-1-indol-2-yl]meth-yl}benzene-sulfonamide.

Two new phenyl-sulfonyl-indole derivatives, namely, -{[3-bromo-1-(phenyl-sulfon-yl)-1-indol-2-yl]meth-yl}--(4-bromo-3-meth-oxy-phen-yl)benzene-sulfonamide, CHBrNOS, (), and ,-bis-{[3-bromo-1-(phenyl-sulfon-yl)-1-indol-2-yl]meth-yl}benzene-sulfonamide, CHBrNOS, (), reveal the impact of intra-molecular π-π inter-actions of the indole moieties as a factor not only governing the conformation of ,-bis-(1-indol-2-yl)meth-yl)amines, but also significantly influencing the crystal patterns. For , the crystal packing is dominated by C-H⋯π and π-π bonding, with a particular significance of mutual indole-indole inter-actions. In the case of , the mol-ecules adopt short intra-molecular π-π inter-actions between two nearly parallel indole ring systems [with the centroids of their pyrrole rings separated by 3.

Synthesis of di/tri-substituted carbazoles involving Pd-mediated Sonogashira coupling of indolyltriflates with aryl acetylenes.

In this study, we present our preliminary findings on the synthesis of carbazole derivatives involving the Sonogashira coupling reaction of 2-(trimethylamino)methylindolyltriflates with aryl acetylenes followed by isomerization, thermal electrocyclization and 1,3-H shift, furnishing the respective di- and tri-substituted carbazoles.

Herniation of the Urinary Bladder Into the Scrotal Sac With Intrascrotal Perforation: A Report of a Rare Case.

This case report describes a rare and complex instance of urinary bladder herniation into the scrotal sac, complicated by intrascrotal perforation. This condition, primarily seen in elderly, obese men, poses significant diagnostic and therapeutic challenges. The patient, an 83-year-old man with a history of obesity and chronic lower urinary tract symptoms, presented with acute scrotal pain and swelling.

Olivopontocerebellar Degeneration in a Young Adult Female: A Case Report of Early Onset and an Uncommon Course.

Olivopontocerebellar degeneration (OPCD) primarily affects individuals in their mid to late adulthood, making its early onset in young adults, particularly postpartum women, a notable rarity. This case report describes OPCD in a 24-year-old female, underscoring the importance of considering neurodegenerative disorders in differential diagnoses even in younger patients. The unique presentation post childbirth adds to the sparse literature on the timing and triggers of neurodegenerative diseases in younger populations, especially in scenarios that might involve hormonal, vascular, or autoimmune shifts such as those occurring postpartum.