Phytochemicals Withanolide N and Dryobalanolide as Potential Bioactive Leads for Developing Anticancer Drugs Targeting Tyrosine-Protein Kinase Mer.

There is a growing interest in harnessing natural compounds and bioactive phytochemicals to accelerate drug discovery and development, including in the treatment of human cancers. Receptor tyrosine kinases (RTKs) are critical regulators of many fundamental cellular processes and have been implicated in cancer pathogenesis as well as targets for anticancer drug development. The members of TAM, Tyro3, Axl, and MERTK subfamily RTKs, especially Mer, affect immune homeostasis in the tumor microenvironment.

The Brilliant Embodiment of Creativity.

Description When someone is given the opportunity to utilize creative liberty, they have access to an infinitely diverse palette of colors, mediums, patterns, and shapes to form a unique amalgamation of artistic styles that conveys different ideas and stories. This painting has been created using watercolor paint, permanent markers, acrylic paint, and multicolored glitter to portray a dream-like, tropical bird in flight. The background of the painting is not as detailed as the prominent, avian figure in question, and that is to leave some ambiguity as to the exact whereabouts of this majestic creature, which is to be determined solely by the observer.

The mediating effects of perceived usefulness and perceived ease of use on nurses' intentions to adopt advanced technology.

This study explored the role of technology systems in influencing nurses' intentions to adopt medical applications that enhance their performance and how technology contributes to improvements in hospital systems. The study examines the intention to use technology through the mediating effects of perceived usefulness and perceived ease of use, with technology sophistication. A random sampling method was employed to gather 687 responses from nurses.

The hidden cost of digital learning: a cross-sectional study assessing the prevalence of computer vision syndrome (CVS) among medical students in Jordan.

Objective: Increased screen time has resulted in widespread computer vision syndrome (CVS) in the digital era. Medical students, who rely heavily on digital screens, are particularly at risk. Our study aims to evaluate the prevalence of CVS among Jordanian medical students, which is a gap in existing knowledge.