Publications by authors named "A Mock"
Article Synopsis
- Whole Exome Sequencing (WES) is a powerful tool in cancer diagnostics that allows for comprehensive analysis of genes, improving the detection of complex biomarkers compared to traditional panel-based methods.
- A study analyzing tissue specimens across 21 NGS centers showed that, although there was a 76% agreement in somatic variant calling, refining filtering criteria improved this to 88%, highlighting the importance of filter settings in variant detection.
- The reliability of detecting specific genomic changes (like CNAs and complex biomarkers) varied among labs, emphasizing the need for improved bioinformatics processes and collaborative testing to minimize discrepancies in future analyses.
Article Synopsis
- This study looked at how many men and women die from overdoses in West Virginia and how different drugs, like alcohol and fentanyl, affect those numbers.
- Researchers found that more men died from overdoses when alcohol was involved, and women have been increasingly affected by alcohol-related deaths.
- The study also noted that men had higher levels of fentanyl in their systems compared to women, which is important to understand to help prevent these deaths.
Demographic, co-intoxicants and other characteristics of citalopram-involved overdose deaths.
Forensic Sci Med Pathol
September 2024
Article Synopsis
- Citalopram, an SSRI, was frequently involved in West Virginia drug-related deaths from 2005 to 2021, making up 4.5% of all cases analyzed, with a majority classified as unintentional.
- Males and females had a notable difference in citalopram-related deaths, with a male to female ratio of 0.9:1, which is lower than the ratio in non-SSRI deaths (2.3:1).
- Over two-thirds of citalopram deaths involved four or more substances, often including opioids like oxycodone, highlighting the complexity of determining citalopram's role in overdose fatalities due to the presence of multiple drugs.
Background And Aims: Cholangiocarcinoma (CCA) is an aggressive malignancy arising from the intrahepatic (iCCA) or extrahepatic (eCCA) bile ducts with poor prognosis and limited treatment options. Prior evidence highlighted a significant contribution of the non-canonical NF-κB signalling pathway in initiation and aggressiveness of different tumour types. Lymphotoxin-β (LTβ) stimulates the NF-κB-inducing kinase (NIK), resulting in the activation of the transcription factor RelB.
View Article and Find Full Text PDFBackground: An estimated 20% of patients with oral and oropharyngeal squamous cell carcinoma (OOSCC) have micrometastases (Mi) or isolated tumor cells (ITC) in the cervical lymph nodes that evade detection by standard histological evaluation of lymph node sections. Lymph node Mi and ITC could be one reason for regional recurrence after neck dissection. The aim of this study was to review the existing data regarding the impact of Mi on the survival of patients with OOSCC.
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