Publications by authors named "A Mochida"
All immune cells must transit from the blood to distal sites such as the lymph nodes, bone marrow, or sites of infection. Blood borne monocytes traffic to the site of inflammation by adhering to the endothelial surface and migrating along endothelial intracellular adhesion molecule 1 (ICAM-1) by their ligand's macrophage 1 antigen (Mac-1) and lymphocyte functional antigen 1 (LFA-1) to transmigrate through the endothelium. Poor patient prognoses in chronic inflammation and tumors have been attributed to the hyper recruitment of certain types of macrophages.
View Article and Find Full Text PDFBrevibacillus thermoruber strain Nabari cells grow as widely spreading dendritic colonies on reasoner's 2A-agar (1.5%) plates at around 55°C but as small motile colonies at 37°C. Motile colonies can be divided into colonies that move in straight or curved lines over long distances (wandering colonies), and colonies that rotate at a fixed location (rotating colonies).
View Article and Find Full Text PDFLeukocytes possess the ability to migrate upstream-against the direction of flow-on surfaces of specific chemistry. Upstream migration was first characterized for T-cells on surfaces comprised of intracellular adhesion molecule-1 (ICAM-1). Upstream migration occurs when the integrin receptor αβ (also known as lymphocyte function-associated antigen-1, or LFA-1) binds to ICAM-1.
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- The study analyzed the effectiveness of a new asthma treatment combining fluticasone furoate, vilanterol, and umeclidinium, approved in Japan on February 18, 2021, by evaluating lung function in asthma patients.
- Researchers conducted a before-after study with 114 asthma outpatients (mostly Japanese), finding significant improvements in lung function tests and asthma control after switching to the new treatment.
- While 66% of subjects wanted to continue with the new treatment, mild local adverse effects were reported in 30% of patients, with no serious side effects observed, marking a promising advancement in asthma management.
Background: The oxidized high-density lipoprotein (oxHDL) is a possible marker for cardiovascular diseases. This study investigated the effects of smoking cessation with varenicline (a partial agonist of nicotinic acetylcholine receptors) on the levels of oxHDL in the serum of subjects compared with those of high-density lipoprotein cholesterol (HDL-C).
Methods: Data of 99 nicotine-dependent adult subjects who visited the smoking cessation outpatient services at International University of Health and Welfare Shioya Hospital were reviewed.