Excessive BMP3b suppresses skeletal muscle differentiation.

Bone morphogenetic protein (BMP)-3b, also known as growth differentiation factor (GDF)-10, belongs to the transforming growth factor (TGF)-β superfamily. Despite being named a BMP, BMP3b is considered as an intermediate between the TGFβ/activin/myostatin and BMP/GDF subgroups of the TGFβ superfamily. Myoblast differentiation is tightly regulated by various cytokines, including the TGFβ superfamily members.

Practice locations of physicians with highly educated spouses in Japan: A cross-sectional study using National Census Data.

Background: Having highly educated spouses may influence physicians' choice of practice location.

Methods: We analyzed a representative physician sample in the 2020 Japan Population Census.

Results: Regression analyses adjusting for physicians' characteristics showed that physicians married to highly educated (with a graduate degree) spouses were less likely to practice in low physician supply areas (LPSAs) than other married physicians (adjusted, 7.

Association Between Coexisting Constipation and Heart Failure Readmission in Patients With Heart Failure - A Nationwide Database Study.

Background: Constipation often coexists with heart failure (HF) and can cause increased blood pressure variability, which may increase the risk of repeated HF admissions. However, large-scale contemporary data regarding the prognostic effect of constipation in patients with HF are lacking.

Methods And Results: We retrospectively identified 556,792 patients admitted for HF for the first time and discharged alive in the fiscal years 2016-2021 using the Japanese Diagnosis Procedure Combination database.

Immobilization of laccases on mechanically ground silk fibroin nanofibers for enhanced stability.

Azo dyes in textile industry effluents pose significant health and environmental risks. Laccase is an enzyme capable of degrading azo dyes, offering an environmentally friendly solution for treating textile wastewater. However, laccases need to be immobilized on specific carriers to enable effective reuse in batch reactors and continuous operation in flow-through reactors.