Publications by authors named "A Miyagawa"
Article Synopsis
- Immune checkpoint inhibitors (ICIs), like pembrolizumab (PEM), are effective against tumors but can cause serious skin side effects (cutaneously adverse events or CAEs), especially when used in combination therapies.
- Severe CAEs may require stopping the immunotherapy, and the risk is higher when ICIs are used with other treatments compared to when they are used alone.
- A case study of 19 women with advanced cervical cancer highlighted the occurrence of severe CAEs, including erythema multiforme and anaphylaxis, stressing the need for tight monitoring of skin reactions during PEM combination therapy to ensure patient safety.
Background: Hay fever (HF) presents with various symptoms, including allergic conjunctivitis and rhinitis, and requires cross-organ treatment. This study assessed the impact of the coronavirus disease 2019 (COVID-19) pandemic on HF treatment trends.
Methods: This retrospective cohort study utilized data from the JMDC database collected between January 2018 and May 2021.
The comprehensive understanding of the orientation of antibodies on a solid surface is crucial for affinity-based sensing mechanisms. In this study, we demonstrated that the orientation of primary antibodies modified on carboxy-functionalized polystyrene (PS) particles can be analyzed using zeta potential behavior at different pH based on the combined Gouy-Chapman-Stern model and the acid dissociation of carboxy groups and antibodies. We observed that at low surface concentrations of the primary antibody, a side-on orientation was predominant.
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- The study addresses challenges in detecting reactions between isotropic particles by introducing a new detection method for DNA that uses Janus particles (JPs), which have different properties on each side.
- The aggregation of JPs is triggered by a process called sandwich hybridization with target DNA, and changes in particle size are monitored using dynamic light scattering (DLS), achieving detection limits at very low concentrations.
- This innovative detection approach emphasizes the versatility of Janus particles, allowing for potential modifications to detect various molecules, highlighting its broad applications in sensitive detection across different fields.
Some cases of coronary artery occlusion by prosthetic valves after surgical aortic valve replacement (SAVR) may be diagnosed and treated during operation if it is difficult to be separated from cardiopulmonary bypass. We present a case of a 74-year-old woman with symptomatic aortic stenosis due to bicuspid valve and a narrow aortic valve annulus. SAVR was considered to be feasible over transcatheter aortic valve implantation given her anatomy and frailty.
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