Publications by authors named "A Miuli"
Article Synopsis
- - Methylphenidate (MPH), often used to treat ADHD, is increasingly misused by individuals with co-occurring psychiatric and substance use disorders, raising concerns about dependence and adverse effects.
- - A systematic review conducted in 2024 analyzed 12 studies, focusing on patterns of MPH misuse among patients with various psychiatric disorders, including conduct, mood, and anxiety disorders.
- - The results showed a significant correlation between MPH misuse and individuals with psychiatric disorders, particularly those also suffering from Alcohol Use Disorder, highlighting the need for targeted interventions and monitoring.
Club Drugs and Psychiatric Outcomes: A Descriptive Case Series from Spain.
Pharmaceuticals (Basel)
October 2024
Background: illegal drugs significantly contribute to global health issues, with health complications often occurring not only in regular users with Substance Use Disorders (SUDs) but also in first-time and occasional users.
Methods: this study examines five clinical cases from a public hospital in Ibiza, Spain, where patients presented with acute psychiatric symptoms due to recreational drug use.
Results: Contrary to previous studies on SUDs, our patients typically had higher education levels and stable employment.
Article Synopsis
- Treatment-Resistant Depression (TRD) affects about 30% of people with Major Depressive Disorder, and a new nasal spray called Esketamine (ESK-NS) has been approved to help treat it when combined with certain medications.
- Researchers wanted to see if combining Vortioxetine, another antidepressant, with ESK-NS was just as good or better than the usual treatment.
- The results showed that the Vortioxetine and ESK-NS combo worked well to reduce depression and had fewer side effects, suggesting it could be a better option, but more research is needed to be sure.
Background: This systematic review aims to comprehensively explore the impact of psychostimulant substances on neurotrophic and inflammatory pathways, including brain-derived neurotrophic factor (BDNF), pro-BDNF, cortisol, dehydroepiandrosterone sulfate (DHEAS), thiobarbituric acid reactive substances (TBARS), interleukins, and the role of genetic factors. The study seeks to address existing gaps in the literature by providing a thorough evaluation of neurotrophic and inflammatory system alterations associated with different stages of psychostimulant dependence for a more nuanced understanding of substance use disorder (SUD) neurobiology.
Methods: A systematic review was conducted in PubMed, Scopus, and Web of Science databases following the PRISMA guidelines.