Immunolocalization and expression of bone morphogenetic proteins 2 and 4 in fracture healing.

Recently, it has become increasingly evident that fracture healing involves a complex interaction of many local and systemic regulatory factors. The roles of some of these growth factors have been described; however, little is understood about the presence of the bone morphogenetic proteins in fracture repair, despite the fact that they are the most potent osteoinductive proteins known. This study defines and characterizes the physiologic presence, localization, and chronology of the bone morphogenetic proteins in fracture healing with an established rat fracture healing model.

A biomechanical evaluation of the long stem intramedullary hip screw.

Despite the advantages associated with short-stem intramedullary hip screw devices for the treatment of intertrochanteric fractures, recent reports have shown an increased incidence of femoral shaft fractures after their insertion. These findings led to the hypothesis that an intramedullary hip screw with a longer stem may more effectively redistribute loads to the distal end of the femoral shaft, where they may be more readily absorbed by the increased bony cross-sectional area. To characterize the load patterns of a long-stem device in the femur, 10 fresh-frozen adult femurs were instrumented with unidirectional strain gauges.

Fatigue testing of cerclage stainless steel wire fixation.

Because wire fixation continues to be used extensively in the practice of orthopaedic surgery, despite a high incidence of wire breakage, understanding the mechanism of this failure is of important clinical interest. The aim of this study was to investigate the failure of cerclage stainless steel wire using an in vitro cyclic loading device. A stainless steel testing fixture consisting of two half cylinders with a combined diameter of 2.