Publications by authors named "A Mirandola"
Background And Purpose: Radiotherapy for paediatric posterior fossa tumours may cause complications in the brainstem and upper spinal cord due to high doses. With proton therapy (PT) this risk may increase due to higher relative biological effectiveness (RBE) from elevated linear energy transfer (LET). This study assesses variations in LET in the brainstem and spinal cord in proton treatment plans from European centres.
View Article and Find Full Text PDFBackground: A passive dosimeter framework for the measurement of dose in carbon ion beams has yet to be characterized or implemented for regular use.
Purpose: This work determined the dose calculation correction factors for absorbed dose in thermoluminescent dosimeters (TLDs) in a therapeutic carbon ion beam. TLD could be a useful tool for remote audits, particularly in the context of clinical trials as new protocols are developed for carbon ion radiotherapy.
Article Synopsis
- Image-guided treatment adaptation using CycleGAN for synthetic CT generation is a significant advancement in particle therapy for young cancer patients.
- The study involved processing CBCT scans from 15 pelvic patients to create synthetic CT images, which were evaluated against verification CT scans for quality.
- Results showed that despite some limitations, the CycleGAN method produced satisfactory synthetic CT images that could improve treatment efficacy in pediatric oncology.
Article Synopsis
- The study aimed to assess the effectiveness and side effects of high-dose carbon ion radiation therapy (CIRT) in treating patients with malignant peripheral nerve sheath tumors (MPNSTs), analyzing data from 23 patients treated between 2013 and 2020.
- Results showed promising overall survival rates of approximately 82% at 1 year and 61.5% at 2 years, alongside local relapse-free survival rates of 65% and 48.8% at the same intervals, with no treatment-related deaths reported.
- While some patients experienced acute (43.5%) and late (34.8%) toxicities mostly classified as grade 2 or higher, there were no severe toxicities (grade 4)
Background: We studied the poorly-known dynamics of circulating DNA (cir-nDNA), as monitored prospectively over an extended post-surgery period, in patients with cancer.
Methods: On patients with stage III colon cancer (N = 120), using personalised molecular tags we carried out the prospective, multicenter, blinded cohort study of the post-surgery serial analysis of cir-nDNA concentration. 74 patients were included and 357 plasma samples tested.