Publications by authors named "A Mingels"
Monitoring of myocardial injury by serial measurements of QRS area and T area: The MaastrICCht cohort.
Ann Noninvasive Electrocardiol
September 2024
Background: Manually derived electrocardiographic (ECG) parameters were not associated with mortality in mechanically ventilated COVID-19 patients in earlier studies, while increased high-sensitivity cardiac troponin-T (hs-cTnT) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) were. To provide evidence for vectorcardiography (VCG) measures as potential cardiac monitoring tool, we investigated VCG trajectories during critical illness.
Methods: All mechanically ventilated COVID-19 patients were included in the Maastricht Intensive Care Covid Cohort between March 2020 and October 2021.
Article Synopsis
- The study focuses on improving the detection of periprocedural myocardial infarction (PMI) after coronary artery bypass grafting (CABG) by analyzing the changes in cardiac biomarker CK-MB over time.
- It involved 635 patients with 1589 CK-MB measurements, where the majority showed no signs of PMI, pinpointing key factors like patient sex and surgical specifics that influence CK-MB levels.
- A web-based application was developed to model CK-MB kinetics; the model achieved notable diagnostic accuracy, indicating its potential for wider use in monitoring and validating other cardiac biomarkers.
Cardiac troponin concentrations following exercise and the association with cardiovascular disease and outcomes: rationale and design of the prospective TREAT cohort study.
BMJ Open Sport Exerc Med
June 2024
Exercise can produce transient elevations of cardiac troponin (cTn) concentrations, which may resemble the cTn release profile of myocardial infarction. Consequently, clinical interpretation of postexercise cTn elevations (ie, values above the 99th percentile upper reference limit) remains challenging and may cause clinical confusion. Therefore, insight into the physiological versus pathological nature of postexercise cTn concentrations is warranted.
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- Cardiac troponin T (cTnT) is crucial for diagnosing heart attacks (MI) but is often elevated in patients with end-stage renal disease (ESRD), which complicates interpretation of results.
- The study assessed how different blood collection methods (serum, lithium-heparin plasma, and EDTA plasma) affect cTnT composition and concentration in both MI and ESRD patients.
- Findings showed that while cTnT concentration remains consistent across blood types, the degradation pattern of cTnT varies significantly, with MI patients showing larger proteoforms and ESRD patients displaying small fragments, which is important for developing accurate diagnostic assays.
Background: Coronary artery calcification (CAC) is associated with poor outcome in critically ill patients. A deterioration in cardiac conduction and loss of myocardial tissue could be an underlying cause. Vectorcardiography (VCG) and cardiac biomarkers provide insight into these underlying causes.
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