Publications by authors named "A Minelli"
Schizophrenia (SCZ), bipolar (BD) and major depression disorder (MDD) are severe psychiatric disorders that are challenging to treat, often leading to treatment resistance (TR). It is crucial to develop effective methods to identify and treat patients at risk of TR at an early stage in a personalized manner, considering their biological basis, their clinical and psychosocial characteristics. Effective translation of theoretical knowledge into clinical practice is essential for achieving this goal.
View Article and Find Full Text PDFSurvival Outcomes with Regorafenib and/or Trifluridine/Tipiracil Sequencing to Rechallenge with Third-Line Regimens in Metastatic Colorectal Cancer: A Multicenter Retrospective Real-World Subgroup Comparison from the ReTrITA Study.
Curr Oncol
December 2024
Background: There is ongoing discussion around the optimal course of treatment for metastatic colorectal cancer (mCRC) following the second line. Trifluridine/tipiracil (T) and regorafenib (R) have been the mainstay of therapy in this situation, as they both increased overall survival (OS) in comparison to a placebo. Despite the paucity of evidence, therapy rechallenge is also recognized as an option for practical use.
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- Mitochondrial dysfunction has been noted in bipolar disorder (BD), but its impact on the disorder's origins and treatment response remains under-researched.* -
- A study comparing mitochondrial DNA copy number (mtDNA-cn) in 89 BD patients and 78 healthy controls found that BD patients had significantly higher mtDNA-cn levels, especially those treated with other mood stabilizers as opposed to lithium.* -
- The results indicate that while BD may be linked to mitochondrial issues, lithium treatment appears to lower mtDNA-cn levels, suggesting a potential restoration of mitochondrial function that doesn't necessarily correlate with how well patients respond to the medication.*
Article Synopsis
- * The study, funded by the Italian Ministry of Health, aims to explore how inflammation contributes to depression onset, treatment resistance, and related health issues through various scientific analyses and human cohorts.
- * Over two years, the research will enhance understanding of inflammation's role in MDD and related disorders, potentially leading to new personalized treatment strategies.
Article Synopsis
- Silver-Russell Syndrome (SRS) is a disorder that leads to growth failure, characteristic physical features, and feeding issues, with significant genetic causes remaining unclear in many cases.
- The study aimed to assess the genetic variants in undiagnosed SRS patients and determine if (epi)genetic patients show distinct characteristics compared to genetic patients.
- Findings revealed that only 9.1% of patients had identifiable pathogenic variants, emphasized body asymmetry as a key trait in (epi)genetic SRS, and recommended including IGF1R sequencing in the diagnostic process for SRS.