Herein, I will review our efforts to develop a comprehensive and robust model for the estimation of the first oxidation potential, , and antioxidant activity, AA, of flavonoids that would, besides enabling fast and cheap prediction of and AA for a flavonoid of interest, help us explain the relationship between , AA and electronic structure. The model development went forward with enlarging the set of flavonoids and, that way, we had to learn how to deal with the structural peculiarities of some of the 35 flavonoids from the final calibration set, for which the measurements were all made in our laboratory. The developed models were simple quadratic models based either on atomic spin densities or differences in the atomic charges of the species involved in any of the three main oxidation mechanisms.
View Article and Find Full Text PDFUnlabelled: The technical complexity of gene expression profiling in routine practice has necessitated the use of surrogate molecular classification of breast cancer, based on immunohistochemical analyses.
Background And Objectives: The aim of this study was to compare the differences between histological and molecular subtypes of invasive lobular carcinoma (ILC) of the breast, in order to be able to predict the behavior and prognosis of the disease, as well as to effectively determine therapy.
Material And Methods: This study included 263 cases of breast ILC diagnosed over a seven-year period.