Photochemical cyclopropanation in aqueous micellar media - experimental and theoretical studies.

While in nature, reactions occur in water-based confined compartments, for a long time, water has been often regarded as an unsuitable medium for organic reactions. We have, however, found that photochemical cyclopropanation of styrenes with diazo compounds or their precursors can be performed in micellar systems. COSMO-RS studies revealed that the reactivity correlates with the predicted critical micelle concentration (CMC), with higher CMC values delivering higher yields.

Phenylketonuria patients' and their parents' knowledge and attitudes to the daily diet - multi-centre study.

Background: The aim of the study was to assess both patients' and their parents' knowledge of phenylketonuria (PKU) treatment and compliance with PKU diet.

Methods: The study included 173 PKU patients aged 10-19 and 110 parents of PKU children who were enrolled in the study on the basis of questionnaire data. The study also included 45 patients aged ≥20.

Phenylketonuria patients' and their parents' acceptance of the disease: multi-centre study.

Purpose: Phenylketonuria (PKU) still poses a therapeutic challenge for patients and medical professionals. The aim of the study was to assess both patients' and their parents' acceptance of the disease.

Methods: The study included 218 PKU patients and 178 parents of PKU children who were enrolled in the study on the basis of questionnaire data.

Effect of multifocal lens glasses on the stepping patterns of novice wearers.

Multifocal lens glasses (MfLs) negatively affect vision, increase falling risk and contribute to gait changes during stepping. Previous studies on the effects of MfLs on gait have focused on experienced wearers. Thus, the initial response of first-time wearers, who may face significant challenges in adapting to these glasses, is not well understood.

Impact of lipophilic antioxidants and level of antibodies against oxidized low-density lipoprotein in Polish children with phenylketonuria.

The treatment of phenylketonuria (PKU) patients constitutes a phenylalanine (Phe) intake restriction in their diet, which is achieved by adding a special Phe-free amino acid mixture to the diet. It has been reported that this diet could have some micronutrient deficiency. Several authors have also reported an increased oxidative stress or impaired antioxidant status in human and experimental PKU.